Targeting cancer stem cell pathways for cancer therapy (DOI: 10.1038/s41392-020-0110-5) (Q8449)

Research article: Signal Transduct Target Ther; 2020 ; 5 8

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English	Targeting cancer stem cell pathways for cancer therapy (DOI: 10.1038/s41392-020-0110-5)	Research article: Signal Transduct Target Ther; 2020 ; 5 8

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Cancer stem cells

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title

Targeting cancer stem cell pathways for cancer therapy (English)

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COVID-19 Open Research Dataset (CORD-19). 2020.

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10.1038/s41392-020-0110-5

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Signal Transduct Target Ther

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PMC7005297

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32047658

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cc-by

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7 February 2020

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Author

Liqun Yang (1st author of 10.1038/s41392-020-0110-5)

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Series Ordinal

1

Pengfei Shi (2nd author of 10.1038/s41392-020-0110-5)

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Series Ordinal

2

Gaichao Zhao (3rd author of 10.1038/s41392-020-0110-5)

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Series Ordinal

3

Jie Xu (4th author of 10.1038/s41392-020-0110-5)

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Series Ordinal

4

Wen Peng (5th author of 10.1038/s41392-020-0110-5)

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Series Ordinal

5

Jiayi Zhang (6th author of 10.1038/s41392-020-0110-5)

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Series Ordinal

6

Guanghui Zhang (7th author of 10.1038/s41392-020-0110-5)

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Series Ordinal

7

Xiaowen Wang (8th author of 10.1038/s41392-020-0110-5)

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Series Ordinal

8

Zhen Dong (9th author of 10.1038/s41392-020-0110-5)

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Series Ordinal

9

Fei Chen (10th author of 10.1038/s41392-020-0110-5)

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Series Ordinal

10

Hongjuan Cui (11th author of 10.1038/s41392-020-0110-5)

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Series Ordinal

11

has part

Section 1: Introduction (from DOI: 10.1038/s41392-020-0110-5)

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Section 2: The concept of CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 2.1: Biological characteristics of CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 2.2: Isolation and identification of CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3: Factors regulating CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.1: Major transcription factors in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2: Major signaling pathways in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2.1: Wnt signaling pathway in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2.2: Notch signaling pathway in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2.3: Hh signaling pathway in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2.4: NF-kappaB signaling pathway in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2.5: JAK-STAT signaling pathway (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2.6: TGF/SMAD signaling pathway in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2.7PI3K/AKT/mTOR signaling pathway in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2.8: PPAR signaling pathways in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.2.9: Interactions between signaling pathways in CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.3: The microenvironment of CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.3.1: Vascular niche microenvironments and CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.3.2: The hypoxia microenvironment and CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.3.3: Tumor-associated macrophages and CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.3.4: Cancer-associated fibroblasts and CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.3.5: Cancer-associated MSCs and CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.3.6: Extracellular matrix and CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 3.3.7: Exosomes in the TME and CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 4: Therapeutic targeting of CSCs (from DOI: 10.1038/s41392-020-0110-5)

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Section 4.1: Agents targeting CSC-associated surface biomarkers in clinical trials (from DOI: 10.1038/s41392-020-0110-5)

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Section 4.2: Agents targeting CSC-associated signaling pathways in clinical trials (from DOI: 10.1038/s41392-020-0110-5)

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Section 4.3: Targeting the CSC microenvironment (from DOI: 10.1038/s41392-020-0110-5)

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Section 4.4: CSC-directed immunotherapy (from DOI: 10.1038/s41392-020-0110-5)

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Section 5: Conclusions and perspectives (from DOI: 10.1038/s41392-020-0110-5)

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Competing interests (from DOI: 10.1038/s41392-020-0110-5)

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